Disseminated herpes virus

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Abstract Disseminated neonatal herpes simplex virus HSV infection is characterized by progressive multiple organ failure and high mortality rates. The Case. Figure Figure. Could neonatal disseminated herpes simplex virus infections be treated earlier?

J Infect. Whitley R. Neonatal herpes simplex virus infection. Curr Opin Infect Dis. A bone marrow smear showed hypocellular marrow with histiocytes and hemophagocytosis. The diagnosis of HLH was confirmed, and the patient was treated with methylprednisolone pulse therapy on days On day 5, despite initial improvement of the fever and sore throat, multiple, new, small bullae developed on the patient's face, trunk, and extremities.

Additional testing showed that he was positive for HSV-specific immunoglobulin M and immunoglobulin G. A subsequent direct antigen test of a bulla sample was positive for HSV HH, HK, TH: acquisition of the histopathological data, interpretation of results, and revision of the manuscript. All authors read and approved the final manuscript.

Correspondence to Noritaka Sekiya. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Kurosawa, S. Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

BMC Infect Dis 19, 65 Download citation. Received : 14 September Accepted : 11 January Published : 17 January Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Case report Open Access Published: 17 January Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement Shuhei Kurosawa 1 , Noritaka Sekiya ORCID: orcid.

Case presentation A year-old male was admitted to our hospital with a 1-week history of fever and sore throat. Conclusion Disseminated HSV-2 infection should be considered as one of the differential diagnoses in patients with pharyngotonsillitis and impaired liver function of unknown etiology even if there are no genital lesions.

Full size image. Discussion and conclusions In the present case, pharyngotonsillitis developed as an initial manifestation of disseminated HSV-2 infection without genital involvement.

Table 1 Adult disseminated HSV-2 infection: 15 reported cases and the presented case Full size table. References 1. Article Google Scholar 2. Article Google Scholar 3. Article Google Scholar 5. Article Google Scholar Article Google Scholar Download references.

Acknowledgements The authors would like to thank the patient described in this case for allowing us to share it with the scientific community. Funding None. Availability of data and materials Not applicable. View author publications. Ethics declarations Ethics approval and consent to participate Not applicable.

Consent for publication Written informed consent for publication was obtained from the patient. Competing interests The authors declare that they have no competing interest. About this article. Cite this article Kurosawa, S. Copy to clipboard. Contact us Submission enquiries: bmcinfectiousdiseases biomedcentral. Select personalised ads. Apply market research to generate audience insights.

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